2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Xanthine Oxidase

Xanthine Oxidase

XO

Xanthine Oxidase

Related Products

PDF 0.47 MB

Xanthine oxidase (XO), a versatile molybdoflavoprotein, catalyzes the oxidative hydroxylation of purine substrates (hypoxanthine and xanthine) to produce uric acid and subsequent reduction of oxygen at the flavin center with the generation of reactive oxygen species, either superoxide anion radical or hydrogen peroxide.

Xanthine oxidase is an important enzyme of purine catabolism pathway and has been associated directly in pathogenesis of gout and indirectly in many pathological conditions like cancer, diabetes and metabolic syndrome. The selective inhibition of xanthine oxidase may result in a broad spectrum therapeutic use for gout, cancer, inflammation and oxidative damage.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-W392836
    2'-O-Methyl-5'-O-dmt-inosine-3'-CE-phosphoramidite
    		98.0%
    2'-O-Methyl-5'-O-dmt-inosine-3'-CE-phosphoramidite is a hypoxanthine analog. Hypoxanthine is a kind of purine base mainly present in muscle tissue. And it is a metabolite produced by purine oxidase acting on xanthine. Hypoxanthine has typical anti-inflammatory effects and is a potential endogenous poly(ADP-ribose) polymerase (PARP) inhibitor. It is cytoprotective by inhibiting PAPR activity, inhibiting peroxynitrite-induced mitochondrial depolarization and secondary superoxide production. Hypoxanthine can also be used as an indicator of hypoxia.
    2'-O-Methyl-5'-O-dmt-inosine-3'-CE-phosphoramidite
  • HY-119596
    Eupatoriochromene
    		Inhibitor
    Eupatoriochromene is a chromene and has inhibitory activity against xanthine oxidase (XO).
    Eupatoriochromene
  • HY-N8352
    Baicalein 6-O-glucoside
    		Inhibitor
    Baicalein 6-O-glucoside is a glucuronidation metabolite of Baicalein.
    Baicalein 6-O-glucoside
  • HY-146296
    Xanthine oxidoreductase-IN-1
    The compound is a xanthine oxidoreductase (XOR) inhibitor with high inhibitory concentration, and the value of ic50 is 7.0 nm.
    Xanthine oxidoreductase-IN-1
  • HY-152678
    6-Methoxypurine-9-β-D-5’(R)-C-methylriboside
    6-Methoxypurine-9-β-D-5’(R)-C-methylriboside is a hypoxanthine analog. Hypoxanthine is a kind of purine base mainly present in muscle tissue. And it is a metabolite produced by purine oxidase acting on xanthine. Hypoxanthine has typical anti-inflammatory effects and is a potential endogenous poly(ADP-ribose) polymerase (PARP) inhibitor. It is cytoprotective by inhibiting PAPR activity, inhibiting peroxynitrite-induced mitochondrial depolarization and secondary superoxide production. Hypoxanthine can also be used as an indicator of hypoxia.
    6-Methoxypurine-9-β-D-5’(R)-C-methylriboside
  • HY-N10432
    Xanthine oxidase-IN-8
    		Inhibitor
    Xanthine oxidase-IN-8 (Icarisids J) (Compound 7) is a XOD inhibitor with an IC50 of 29.71 μM.
    Xanthine oxidase-IN-8
  • HY-131271
    Febuxostat impurity 6
    Febuxostat impurity 6 is an impurity of Febuxostat. Febuxostat is selective xanthine oxidase inhibitor with a Ki of 0.6 nM.
    Febuxostat impurity 6
  • HY-177070
    Angexostat
    		Inhibitor
    Angexostat (Compound 2) is an inhibitor of xanthine oxidase. Angexostat exhibits high permeability. Angexostat inhibits CYP2C9 with an IC50 of 18.1 μM. Angexostat can be studied in research for xanthine oxidase-related diseases such as hyperuricemia and gout.
    Angexostat
  • HY-146560
    Xanthine oxidase-IN-6
    		Inhibitor
    Xanthine oxidase-IN-6 (Compound 6c) is a potent, orally active, mixed-type xanthine oxidase (XOD) inhibitor with an IC50 value of 1.37 µM. Xanthine oxidase-IN-6 shows strong anti-hyperuricemia and renal protective activity.
    Xanthine oxidase-IN-6
  • HY-151173
    XO/COX/LOX-IN-1
    		Inhibitor
    XO/COX/LOX-IN-1 (compound 7i) is a potent xanthine oxidase/cyclooxygenases/lipoxygenases (XO/COX/LOX) inhibitor. XO/COX/LOX-IN-1 can be used in studies of inflammation, cancer and metabolic diseases.
    XO/COX/LOX-IN-1
  • HY-151974
    Xanthine oxidoreductase-IN-4
    		Inhibitor
    Xanthine oxidoreductase-IN-4 is an orally active xanthine oxidoreductase (XOR) inhibitor. Xanthine oxidoreductase-IN-4 has inhibitory activity against XOR with an IC50 value of 29.3 nM. Xanthine oxidoreductase-IN-4 can be used for the research of hyperuricemia.
    Xanthine oxidoreductase-IN-4
  • HY-167709
    Azacosterol
    		Inhibitor
    Azacosterol (20.25-Diazacholesterol), also known as Diazasterol, acts as a DHCR24 inhibitor and initiates a cascade of reactions in cortical neurons after being administered orally or via intraperitoneal injection.
    Azacosterol
  • HY-N10741
    Ellagic acid 4-O-β-D-xylopyranoside
    		Inhibitor
    Ellagic acid 4-O-β-D-xylopyranoside is a natural ellagitannin with antimicrobial activity. Ellagic acid 4-O-β-D-xylopyranoside is an xanthine oxidase inhibitor with an 50 of 2.1 μg/mL.
    Ellagic acid 4-O-β-D-xylopyranoside
  • HY-150257
    Xanthine oxidase-IN-10
    		Inhibitor
    Xanthine oxidase-IN-10 (XO8 analog) is an xanthine oxidase (XO) inhibitor.
    Xanthine oxidase-IN-10
  • HY-152696
    6-O-Methylinosine
    6-O-Methylinosine is a hypoxanthine analogue. Hypoxanthine is a kind of purine base mainly present in muscle tissue. And it is a metabolite produced by purine oxidase acting on xanthine. Hypoxanthine has typical anti-inflammatory effects and is a potential endogenous poly(ADP-ribose) polymerase (PARP) inhibitor. It is cytoprotective by inhibiting PAPR activity, inhibiting peroxynitrite-induced mitochondrial depolarization and secondary superoxide production. Hypoxanthine can also be used as an indicator of hypoxia.
    6-O-Methylinosine
  • HY-W104467
    (+/-)-Epicatechin
    		Inhibitor
    (+/-)-Epicatechin is a xanthine oxidase inhibitor with an IC50 of 982.14 μM, and can be found in Semen Plantaginis (Plantago seed). (+/-)-Epicatechin can be used in research on diseases such as hyperuricemia and gout .
    (+/-)-Epicatechin
  • HY-N1162
    Tetrahydroamentoflavone
    		Inhibitor
    Tetrahydroamentoflavone (Amentoflavanone) is a potent xanthine oxidase (XO) inhibitor. Tetrahydroamentoflavone has inhibitory activity for XO with IC50 and Ki values of 92 nM and 0.982 μM, respectively. Tetrahydroamentoflavone can be used for the research of inflammatory disorders and gout.
    Tetrahydroamentoflavone
  • HY-N10433
    Xanthine oxidase-IN-9
    		Inhibitor
    Xanthine oxidase-IN-9 (Icarisids E) (Compound 2) is a potent xanthine oxidase (XOD) inhibitor with an IC50 of 31.81 μM.
    Xanthine oxidase-IN-9
  • HY-N10411
    Morin 3-O-β-D-glucopyranoside
    		Inhibitor
    Morin 3-O-β-D-glucopyranoside is a natural flavonoid with antifungal, anticancer and antioxidant activities. Morin 3-O-β-D-glucopyranoside inhibits reverse transcriptase, protein-tyrosine kinase and xanthine oxidase, and also shows anti-HIV, antiarteriosclerotic, and superoxide scavenging activities.
    Morin 3-O-β-D-glucopyranoside
  • HY-W012658R
    2-Methylacetophenone (Standard)
    		Inhibitor
    2-Methylacetophenone (O-Methylacetophenone) (Standard) is the analytical standard of 2-Methylacetophenone (HY-W012658). This product is intended for research and analytical applications. 2-Methylacetophenone is a xanthine dehydrogenase (XDH) inhibitor 2-Methylacetophenone competitively binds to the XDH active site, blocking the pathway for xanthine to be converted to uric acid. 2-Methylacetophenone can be used for the study of hyperuricemia.
    2-Methylacetophenone (Standard)
Cat. No. Product Name / Synonyms Application Reactivity